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Accueil du site > OLD Actualités > Summerschool - Biosensing with channels

Summerschool - Biosensing with channels

21-27 Aout 2010 - Berder Island - Brittany - France

- Registration
- Program


PNG - 501.4 ko

Subject of the summerschool

In biological systems, ions and macromolecules are transported across lipid membranes by highly selective nanoscaled protein channels. The study of these transport processes and their imitation in artificial structures, fabricated by chemical synthesis and micro-fabrication, offer many opportunities for applications in ultrasensitive detection of molecules : rapid sequencing of DNA or RNA, studies of conformation (secondary structure of RNA, protein folding), or molecular interaction between proteins or between proteins and nucleic acids. The integration of channels and pores in the nanometer micro-fluidic devices or on deposited lipid bilayers on solid surfaces leads to the creation of new bio-sensors. The techniques of "Patch-clamp on a chip" thus become indispensable in drug screening.

The area attracts many researchers from different disciplines : biologists, physicists, chemists and engineers. Classes are devoted to be accessible to multidisciplinary students. They will be given by internationally recognized speakers. Participating students and postdocs will have the opportunity to present and discuss their own research in poster sessions and student seminars.

- Registration

Working Program

The program will include lectures on the following topics :

  •  natural channels : ion channels, mechano-sensitive channels, porins, toxins, nuclear pores, translocons,
  •  natural processes of transport of ions and macromolecules : biopolymer synthesis, transport of nucleic acids through nuclear pores, infection of cells by viruses, translocation and secretion of proteins,
  •  biophysics of lipid membranes, fusion, fission, poration, exo- and endocytosis,
  •  chemical synthesis of artificial channels,
  •  microfabrication, functionalization and use of artificial nanopores and nanotubes,
  •  electrical and optical detection of the transport of molecules at the scale of one single channel,
  •  proteins translocation and folding,
  •  forces measurement and conformations detection by translocation,
  •  physics of confined polymers,
  •  lipid bilayers and channels based biosensors,
  •  electronic detection of bio-macromolecules.

One half-day will be devoted to presentations by companies working in the field of microfluidics, patch-clamp on a chip, electrophysiology, drug screening and biosensors.

One evening of popularization of the subjects of the school will be organized.

Local Organizing Committee

Loïc Auvray, Philippe Guégan, Laurent Bacri, Jérôme Mathé and Jeanine Tortajada (université d’Évry)

Frank Artzner et Denis Morineau (université de Rennes)

Charlie Gosse (CNRS, LPN)

Scientific Committee

Chaiman : Mathias Winterhalter (Jakobs University Bremen)

Members : Sergey Bezrukov (NIH, Bethesda), Ulrich Bockelman (ESPCI), Yong Chen (ENS), Cees Dekker (Kavli Institute, Delft), Jacques Gierak (CNRS LPN), Xavier Gidrol (DSV, CEA), Ulrich Keyser (Cavendish Laboratory, Cambridge), Elie Raphaël (ESPCI), Jeanine Tortajada (université d’Évry)

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