Presentation of the team
The team has expertise in mass spectrometry (MS) applied to the study of small systems (about twenty atoms) up to very large bio-macromolecular complexes (> 500 kDa). It develops new original analytical methods by MS, in particular through innovative couplings (CE-MS and SPR-MS) and dynamic labeling processes using synchrotron radiation. For this, it has access to Very Large Equipment (TGE), such as the CLIO free-electron laser and the SOLEIL synchrotron. Through these new methods, the team is seeking to remove analytical obstacles (large and flexible buildings resistant to the usual bio-structural methods, sulfo-proteomics, analysis of biomolecular interactions, structural and functional decoding of glycosaminoglycans) and to obtain data new structural (use of new gas phase reactivities on small systems: IRMPD, ETD, PTR, or new ionization methods for synthetic polymers: photoionization). This research aims to establish relationships between the structure and the physico-chemical properties of the objects studied, the mechanisms of biological action of proteins (proteomics) and carbohydrates (glycomics), as well as to understand the properties of interactions (mechanisms, dynamics) between biomolecules, between biomolecules and metal ions or between biomolecules and synthetic polymers. They are part of Biology-Health and Environmental Chemistry issues. These multidisciplinary thematic fields naturally lead the team to interact with the other teams of the Unit (call for projects, thesis and joint work), these cross-functional relations being a strong desire of the team. Beyond the Unit, the team is also closely linked to its socio-economic environment (GENOPOLE, companies in the South of France, General Council of 91, University of Paris-Saclay) to which it offers access to its experimental devices. (platform) and its bio-analytical expertise.