My research is at the crossroads of biomaterials and biophysics. I have developed an expertise in Atomic Force Microscopy (AFM) to study biological materials, from biopolymers to living cells.
- My Ph.D. work (2006–2010, University of Paris Diderot and Paris Descartes, France) focused on studying neuronal growth on modified surfaces. I showed that spatial variations in adhesion energy could dramatically affect cell adhesion and differentiation into neurons. This might help in designing new biocompatible surfaces for nerve regeneration.
Lamour et al. Colloids Surf B 2009
Lamour et al. Biomaterials 2010
Lamour et al. JBMR-A 2011
Lamour et al. J Chem Educ 2011
Lamour et al. Macromol Biosci 2015
- My first postdoc (2011–2016, University of British Columbia, Vancouver, Canada) focused on amyloids. I connected their mechanical properties with the intermolecular interactions in the fibrils. This helps understanding the molecular origins of amyloid diseases (e.g. Parkinson’s, prion diseases) and may help in designing amyloid-based nanomaterials with tailored mechanical properties.
Lamour et al. ACS Nano 2014
Lamour et al. Source Code Biol Med 2015
Lamour et al. Biophys J 2017
Nassar,…, and Lamour. J Phys Chem Lett 2018
Nassar,…, and Lamour. JACS 2019
- In my current work as a Research Engineer (2017-present, University of Evry - Paris Saclay - Genopole grant), I develop new approaches to study the nanomechanics of biomimetic membranes and of living cells, using atomic force microscopy (AFM). This helps understanding mechanisms underlying endocytosis, vesicle formation, and may open up new research avenues in drug design targeting membrane-cytoskeleton interactions.
Meanwhile, I collaborate with research groups in France and abroad to develop AFM activities in the Lambe in a variety of projects. For instance, we have worked with new nanofiber materials exhibiting extraordinary mechanical properties and are currently working on the mechanical properties of disease models of cardiomyocytes.
Lamour et al. Phys Rev X 2020
Christoff-Tempesta et al. Nat Nanotechnol. 2021
Kim et al. Nano Lett. 2021
Cho et al. Nat Commun. 2021
[....more coming !]
Present and past collaborators:
- Pierre Joanne, Onnik Agbulut (Sorbonne Université)
- Julia Ortony (Massachusetts Institute of Technology) Nano Lett 2021; Nat. Nanotechnol. 2020
- Martin Lenz (LPTMS, Universités Paris-Sud and Paris Saclay) Physical Review X 2020;
- Clément Campillo, Sid Labdi, Juan Pelta (Université d'Evry-Paris Saclay) Physical Review X 2020;
- Joerg Gsponer (University of British Columbia) JACS 2019; J Phys Chem Lett 2018; Biophys J 2017;...
- Hongbin Li (UBC) J Phys Chem Lett 2018; JACS 2014; ACS Nano 2014; Biophys J 2012;...
- Neil Cashman (UBC) ACS Chem Neurosci 2018; J Neurosci 2013
- Hao Wu (Harvard Medical School) Biophys J 2017
- Thibault Mayor (UBC) Biophys J 2017
- Xiaonan Lu (UBC) Int J Food Microbiol 2016
- Dieter Bromme (UBC) J Biol Chem 2015; J Biol Chem 2013
- Tuomas Knowles (Cambridge University) Source Code Biol Med 2014
- Nancy Forde (Simon Fraser University) Biomacromolecules 2014
- Ahmed Hamraoui (UPMC) Macromol Biosci 2015; J Biomed Mat Res 2011; Biomaterials 2010;...
- Eric Borguet (Temple University) J Chem Educ 2010; Biomaterials 2010
h-index = 14.
→ Last 5 years: > 700 citations.
Webpages (including citation profile):
On using AFM to study lipid membranes:
– Lamour G., A. Allard, J. Pelta, S. Labdi, M. Lenz, and C. Campillo. Mapping and Modeling the Nanomechanics of Bare and Protein-Coated Lipid Nanotubes. PHYS REV X. 2020; 10:011031-1–17. doi.org/10.1103/PhysRevX.10.011031
On using multifrequency AFM to study amyloids:
– Nassar R., E. Wong, JM. Bui, CK. Yip, HB. Li, J. Gsponer, and G. Lamour. Mechanical anisotropy in GNNQQNY amyloid crystals. J PHYS CHEM LETT. 2018; 9: 4901–09. doi.org/10.1021/acs.jpclett.8b02027
On using statistical mechanics and simulations to study amyloids:
– Lamour G., R. Nassar, PHW. Chan, G. Bozkurt, J. Li, JM. Bui, C. Yip, T. Mayor, HB. Li, H. Wu, and J. Gsponer. Mapping the broad structural and mechanical properties of amyloid fibrils. BIOPHYS J. 2017; 112:584–594. doi.org/10.1016/j.bpj.2016.12.036
On biomaterials surface effects on neuronal growth:
– Lamour G., A. Eftekhari-Bafrooei, E. Borguet, S. Souès, and A. Hamraoui. Neuronal adhesion and differentiation driven by nanoscale surface free-energy gradients. BIOMATERIALS. 2010; 31:3762–71. doi.org/10.1016/j.biomaterials.2010.01.099
On developing technical and software tools:
– Lamour G., JB. Kirkegaard, HB. Li, TPJ. Knowles, and J. Gsponer. Easyworm: an open-source software tool to determine the mechanical properties of worm-like chains. SOURCE CODE BIOL MED. 2014; 9:16.1–16.6. doi.org/10.1186/1751-0473-9-16
Publications (full list):
 Cho Y., T. Christoff-Tempesta, D-Y. Kim, G. Lamour, and J. Ortony. Domain-selective thermal decomposition within supramolecular nanoribbons. NAT COMMUN; in press
Kim D-Y., T. Christoff-Tempesta, G. Lamour, X. Zuo, KH. Ryu, J. Ortony. Morphological
transitions of a photoswitchable aramid amphiphile nanostructure. NANO LETTERS; doi.org/10.1021/acs.nanolett.0c05048
 Christoff-Tempesta T., Y. Cho, DY. Kim, M. Geri, G. Lamour, AJ. Lew, X. Zuo, WR. Lindemann, JH. Ortony. Self-assembly of aramid amphiphiles into ultra-stable nanoribbons and aligned nanoribbon threads. NAT NANOTECHNOL 2021; doi.org/10.1038/s41565-020-00840-w
 Lamour G., A. Allard, J. Pelta, S. Labdi, M. Lenz, and C. Campillo. Mapping and Modeling the Nanomechanics of Bare and Protein-Coated Lipid Nanotubes. PHYS REV X. 2020; 10:011031-1–17. doi.org/10.1103/PhysRevX.10.011031
 Nassar R., E. Wong, J. Gsponer, and G. Lamour. Inverse correlation between amyloid stiffness and size. J AM CHEM SOC. 2019; 141:58–61. doi.org/10.1021/jacs.8b10142
 Nassar R., E. Wong, JM. Bui, CK. Yip, HB. Li, J. Gsponer, and G. Lamour. Mechanical anisotropy in GNNQQNY amyloid crystals. J PHYS CHEM LETT. 2018; 9: 4901–09. doi.org/10.1021/acs.jpclett.8b02027
 Silverman J., E. Gibbs, X. Peng, K. Martens, C. Balducci, J. Wang, M. Yousefi, C.M. Cowan, G. Lamour, et al. A Rational Structured Epitope Defines a Distinct Subclass of Toxic Amyloid-beta Oligomers. ACS CHEM NEUROSCI. 2018; 9:1591–1606. doi.org/10.1021/acschemneuro.7b00469
 Lamour G., R. Nassar, PHW. Chan, G. Bozkurt, J. Li, JM. Bui, C. Yip, T. Mayor, HB. Li, H. Wu, and J. Gsponer. Mapping the broad structural and mechanical properties of amyloid fibrils. BIOPHYS J. 2017; 112:584–594. doi.org/10.1016/j.bpj.2016.12.036
 J. Feng, G. Lamour, R. Xue, MN. Mirvakliki, SG. Hatzikiriakos, J. Xu, HB. Li, S. Wang, X. Lu. Chemical, physical and morphological properties of bacterial biofilms affect survival of encased Campylobacter jejuni F38011 under aerobic stress. INT J FOOD MICROBIOL. 2016; 238:172–182. doi.org/10.1016/j.ijfoodmicro.2016.09.008
 Panwar P., G. Lamour, NCW. Mackenzie, H. Yang, F. Ko, HB. Li, D. Brömme. Changes in structural-mechanical properties and degradability of collagen during ageing-associated modifications. J BIOL CHEM. 2015; 290:23291–306. doi.org/10.1074/jbc.M115.644310
 Lamour G., S. Souès, A. Hamraoui. Substrate-induced PC12 cell differentiation without filopodial, lamellipodial activity or NGF stimulation. MACROMOL BIOSCI. 2015; 15:364–371. doi.org/10.1002/mabi.201400323
 Lamour G., JB. Kirkegaard, HB. Li, TPJ. Knowles, and J. Gsponer. Easyworm: an open-source software tool to determine the mechanical properties of worm-like chains. SOURCE CODE BIOL MED. 2014; 9:16.1–16.6. doi.org/10.1186/1751-0473-9-16
 Kovacic S., L. Samii, G. Lamour, HB. Li, H. Linke, EHC. Bromley, DN. Woolfson, PMG. Curmi, and NR. Forde. Construction and characterization of kilobasepair densely labeled peptide-DNA. BIOMACROMOLECULES. 2014; 15:4065–4072. doi.org/10.1021/bm501109p
 He C., G. Lamour, A. Xiao, J. Gsponer and HB Li. Mechanically Tightening a Protein Slipknot into a Trefoil Knot. J AM CHEM SOC. 2014; 136:11946–11955. doi.org/10.1021/ja503997h
 Lamour G., C. Yip, HB. Li, and J. Gsponer. High intrinsic mechanical flexibility of mouse prion nanofibrils revealed by measurements of axial and radial Young’s moduli. ACS NANO. 2014; 8:3851–3861. doi.org/10.1021/nn5007013
 Ostapchenko VG., FH. Beraldo, AH. Mohammad, YF. Xie, P. Hirata, AC. Magalhaes, G. Lamour, et al. The prion protein ligand, stress-inducible phosphoprotein I (STI1), regulates amyloid-; oligomer toxicity. J. NEUROSCI. 2013; 33:16552–16564. doi.org/10.1523/JNEUROSCI.3214-13.2013
 Cumberworth A. , G. Lamour, M. Babu, and J. Gsponer. Promiscuity as a functional trait: Intrinsically disordered regions as central players of interactomes. BIOCHEM J. 2013; 454:361–369. doi.org/10.1042/BJ20130545
 Panwar P., X. Du, V. Sharma, G. Lamour, M. Castro, HB. Li, and D. Brömme. Effects of cysteine proteases on the structural and mechanical properties of collagen fibers. J BIOL CHEM. 2013; 288:5940–5960. doi.org/10.1074/jbc.M112.419689
 Li YD., G. Lamour, J. Gsponer, P. Zheng and HB. Li. The molecular mechanism underlying mechanical anisotropy of the protein GB1. BIOPHYS J. 2012; 103:2361–2368. doi.org/10.1016/j.bpj.2012.10.035
 Lamour G., S. Souès, and A. Hamraoui. Interplay between long- and short-range interactions drives neuritogenesis on stiff surfaces. J BIOMED MAT RES A. 2011; 99A: 598–606. doi.org/10.1002/jbm.a.33213
 Khorvash M., G. Lamour, and J. Gsponer. Long-time scale fluctuation s of human prion protein determined by restrained MD simulations. BIOCHEMISTRY. 2011; 50: 10191–94. doi.org/10.1021/bi2012756
 Lamour G., A. Eftekhari-Bafrooei, E. Borguet, S. Souès, and A. Hamraoui. Neuronal adhesion and differentiation driven by nanoscale surface free-energy gradients. BIOMATERIALS. 2010; 31:3762–3771. doi.org/10.1016/j.biomaterials.2010.01.099
 Lamour G., A. Hamraoui, A. Buvailo, Y. Xing, S. Keuleyan, V. Prakash, A. Eftekhari-Bafrooei, and E. Borguet. Contact angle measurements using a simplified experimental set-up. J CHEM EDUC. 2010; 87:1403–1407. doi.org/10.1021/ed100468u
 Lamour G., N. Journiac, S. Souès, S. Bonneau, P. Nassoy, and A. Hamraoui. Influence of surface energy distribution on neuritogenesis. COLLOIDS SURF B. 2009; 72:208–218. doi.org/10.1016/j.colsurfb.2009.04.006
Tutorial Lecturer (chargé de TD)
- 2020: Tutorial Lectures/Workshop on Atomic Force Microscopy to Masters' students
→ Theory, imaging modes, mechanics
- 2016: Physics classes to Physics students and Biophysics classes to Biology students at the University of Evry (96 h; 3 × 40 students; 1st year undergraduates)
→ Mechanics, electricity and optics
- 2007: Physics classes to medical school students at the Faculty of Medicine, University of Paris Descartes (66 h; 2 × 40 students; 1st year undergraduates)
→ Diffusion (fluid statics and dynamics), electricity and optics