LAURENT BACRI

LAURENT BACRI

Poste Actuel 

Maître de conférences Hors Classe au département de Physique (Université d'Évry val d'Essonne)

    Bibiographie

    Together with Loïc Auvray, Laurent Bacri has played a pioneering role in advancing the field of nanopores in France from both a polymer physics and soft matter perspective. Over this period, he has cultivated expertise in understanding the dynamics of confined environments, such as nanopores. This research theme has enabled him to explore and contribute to the comprehension of the physical processes governing the confinement of individual biomolecules or nanoparticles. 

    His work has a multidisciplinary character, fostering collaborations with various scientific communities, including surface chemistry, microfluidics, nanomaterials physics, and biology, not only in France (such as ENS Paris-Saclay and C2N) but also across Europe (Freiburg, Bremen, Rome) and in the United States (University of Massachusetts). Over the past decade, his research has been predominantly focused on gaining insights into dynamic processes occurring within solid-state nanopores.

    Recherche

    Activités de recherche

    • Compréhension des processus physiques en milieux confinés.
    • Confinement et transport de chaînes de polymères (PEG), biopolymères (protéines, polysaccharides) dans des canaux protéiques.
    • Confinement et transports dans des nanopores solides.
    • Passivation et fonctionnalisation spécifiquesde nanopores solides.
    • Dispositifs microfluidiques.

    Outils

    • Mesure de courants ioniques.
    • Microscopies optique et fluorescence.

    Collaborations

    Encadrements

    • Wallid Zebbiche, L3 Physique (2024)
    • Jun Du, Master 1 (2023)
    • Yuhua Cai PhD, CSC, ED SDSV, (2022-2025)
    • Izadora Mayumi Fujinami Tanimoto PhD, ED EOBE, (2018-2023)
    • Kamal Bouazza L3 Physique (2019)
    • Izadora Mayumi Fujinami Tanimoto  Master 2 Monabiphot (Nov 2018- Juillet 2019)
    • Izadora Mayumi Fujinami Tanimoto  Master 1 Monabiphot (Juillet-Octobre 2018)
    • Jean Roman PhD, ED SDSV, (2014-2018)

    Enseignements

    • L1 PC: PPEI (TD9H), Scientific Programming  (15H TD)
    • L2 P: Oscillations, Electronics
    • L2 :  Fluid mechanics - Villebon Charpak Institute
    • L3PC: Fluid mechanics, Biophysics
    • M2 PolyBio Mat. (Paris-Saclay): Surface-interfaces (9H), confined media (15H)

    Publications

      2024  
    Ratinho, Laura; Bacri, Laurent; Thiebot, Bénédicte; Cressiot, Benjamin; Pelta, Juan Identification and Detection of a Peptide Biomarker and Its Enantiomer by Nanopore. ACS Cent. Sci.2024, 10, 6, 1167–1178. DOI:10.1021/acscentsci.4c00020
      2023  
    • Greive, S.J., Bacri, L., Cressiot, B. and Pelta, J. 2023-12. Identification of Conformational Variants for Bradykinin Biomarker Peptides from a Biofluid Using a Nanopore and Machine Learning. ACS Nano2023 18, 1, 539–550 DOI: 10.1021/acsnano.3c08433
    • Stierlen, Aïcha ; Greive, Sandra J. ; Bacri, Laurent ; Manivet, Philippe ; Cressiot, Benjamin ; Pelta, Juan Nanopore Discrimination of Coagulation Biomarker Derivatives and Characterization of a Post-Translational Modification ACS Cent. Sci. 2023, Vol. 9, No. 2 p. 228-238 DOI: 10.1021/acscentsci.2c01256
      2022  
    • Fujinami Tanimoto, Izadora Mayumi ; Cressiot, Benjamin ; Greive, Sandra J. ; Le Pioufle, Bruno ; Bacri, Laurent ; Pelta, Juan  Focus on using nanopore technology for societal health, environmental and energy challenges  Nano Res2022, Vol. 15, No. 11 p. 9906-9920 DOI:10.1007/s12274-022-4379-2
    • Fujinami Tanimoto, Izadora Mayumi ; Zhang, Jiayi ; Cressiot, Benjamin ; Pioufle, Bruno Le ; Bacri, Laurent ; Pelta, Juan Dynamics of DNA Through Solid-state Nanopores Fabricated by Controlled Dielectric Breakdown Chemistry An Asian Journal 2022 , Vol. 17, No. 24 DOI: 10.1002/asia.202200888
      2021  
    Fujinami - Tanimoto, Izadora ; Cressiot, Benjamin : Jarroux, Nathalie ; Roman, Jean ; Patriarche, Gilles ; Le Pioufle, Bruno ; Pelta, Juan ; Bacri, Laurent}, Biosensors and Bioelectronics2021, 183 113195 DOI: 10.1016/j.bios.2021.113195
      2020  
    Cressiot, B.; Bacri, L. ; Pelta, J.The Promise of Nanopore Technology: Advances in the Discrimination of Protein Sequences and Chemical Modifications Small Methods, Wiley, 2020, 2000090 DOI: 10.1002/smtd.202000090 Bétermier, Fanny ; Cressiot, Benjamin ; Muccio, Giovanni Di ; Jarroux, Nathalie ; Bacri, Laurent ; della Rocca, Blasco Morozzo ; Chinappi, Mauro ; Pelta, Juan ; Tarascon, Jean-Marie Single-sulfur atom discrimination of polysulfides with a protein nanopore for improved batteries Communications Materials 2020 Vol. 1, No. 1 DOI: 10.1038/s43246-020-00056-4 Tanimoto, I. M. F. ; Cressiot, B. ; Roman, J. ; Jarroux, N. ; Patriarche, G. ; Le Pioufle, B. ; Pelta, J. ; Bacri, L. Nanoparticle detection by solid-state nanopore integrated into a reusable microfluidic device 2020 MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences p. 280-281
      2019  
    Cressiot, B.; Ouldali, H.; Pastoriza-Gallego, M.; Bacri, L.; van der Goot, F. ; Pelta, J. Aerolysin, a powerful protein sensor for fundamental studies and development of upcoming applications  ACS Sensors, 2019 DOI: 10.1021/acssensors.8b01636
      2018  
    1. Roman, J.; Francais, O.; Jarroux, N.; Patriarche, G.; Pelta, J.; Bacri, L. & Pioufle, B. L. Solid-state nanopore easy chip integration in a cheap and reusable microfluidic device for ion transport and polymer conformation sensing ACS Sensors,2018, 3, 2129-2137
    2. Fennouri, A.; Ramiandrisoa, J.; Bacri, L.; Mathé, J. & Daniel, R. Comparative biosensing of glycosaminoglycan hyaluronic acid oligo- and polysaccharides using aerolysin and alpha-hemolysin nanopores The European Physical Journal E, 2018, 41
    3. Roman, J.; Pioufle, B. L.; Auvray, L.; Pelta, J. & Bacri, L. From current trace to the understanding of confined media The European Physical Journal E, 2018, 41
    4. Mamad-Hemouch, H.; Bacri, L.; Huin, C.; Przybylski, C.; Thiebot, B.; Patriarche, G.; Jarroux, N. & Pelta, J. Versatile cyclodextrin nanotube synthesis with functional anchors for efficiency ion channel formation: design, characterization and ion conductance  Nanoscale, 2018, 10, 15303-15316
    5. Pastoriza-Gallego, M.; Thiébot, B.; Bacri, L.; Auvray, L. & Pelta, J. Dynamics of a polyelectrolyte through aerolysin channel as a function of applied voltage and concentrationstar The European Physical Journal E, Springer Nature, 2018, 41
    6. Bacri, L.; Mamad-Hemouch, H.; Przybylski, C.; Thiebot, B.; Patriarche, G.; Jarroux, N. & Pelta, J.
      Biomimetic ion channels formation by emulsion based on chemically modified cyclodextrin nanotubes Faraday Discuss , 2018, 210, 41-54
      2017  

    1.       Roman, J.; Jarroux, N.; Patriarche, G.; Français, O.; Pelta, J.*; Le Pioufle, B.*; Bacri, L.* Functionalized Solid-State Nanopore Integrated in a Reusable Microfluidic Device for a Better Stability and Nanoparticle Detection. ACS Appl Mater Interfaces2017, 9, 41634–41640DOI: 10.1021/acsami.7b14717

      2016  
    Roman, J.; Français, O.; Jarroux, N.; Patriarche, G.; Pelta, J.; Pioufle, B. L. ; Bacri, L. Nanoparticle Electrical Analysis and Detection with a Solid-state Nanopore in a Microfluidic Device Procedia Eng., 2016, 168, 1475 - 1478 DOI: 10.1016/j.proeng.2016.11.425
      2015  
    1. Mamad-Hemouch, H.; Ramoul, H.; Taha, M. A.; Bacri, L.; Huin, C.; Przybylski, C.; Oukhaled, A.; Thiebot, B.; Patriarche, G.; Jarroux, N.*; Pelta, J.* Biomimetic nanotubes based on cyclodextrins for ion-channel applications Nano Letters, 2015, 15, 7748–7754 DOI: 10.1021/acs.nanolett.5b03938
    2. Baaken, G.; Halimeh, I.; Bacri, L.; Pelta, J.; Oukhaled, A.; Behrends, J. C. High-Resolution Size-Discrimination of Single Nonionic Synthetic Polymers with a Highly Charged Biological Nanopore. ACS Nano, 2015, 9, 6443-6449 DOI: 10.1021/acsnano.5b02096
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