LAURENT BACRI

LAURENT BACRI

 

Associate Professor 

Physics Department

 

 

    Bibliography

    Together with Loïc Auvray, Laurent Bacri has played a pioneering role in advancing the field of nanopores in France from both a polymer physics and soft matter perspective. Over this period, he has cultivated expertise in understanding the dynamics of confined environments, such as nanopores. This research theme has enabled him to explore and contribute to the comprehension of the physical processes governing the confinement of individual biomolecules or nanoparticles.

     

    His work has a multidisciplinary character, fostering collaborations with various scientific communities, including surface chemistry, microfluidics, nanomaterials physics, and biology, not only in France (such as ENS Paris-Saclay and C2N) but also across Europe (Freiburg, Bremen, Rome) and in the United States (University of Massachusetts). Over the past decade, his research has been predominantly focused on gaining insights into dynamic processes occurring within solid-state nanopores.

    Research

    Research activities

    • Understanding of physical processes in confined environments.
    • Confinement and transport of polymer chains (PEG), biopolymers (proteins, polysaccharides) in protein channels.
    • Confinement and transport in solid nanopores.
    • Functionalization of solid nanopores.
    • Microfluidic devices.

    Tools

    • Measurement of ionic currents.
    • Optical and fluorescence microscopy.

    Collaborations

     

     

    Supervising

    • Kamal Bouazza L3 Physics (2019)

    • Izadora Mayumi Fujinami Tanimoto  Master 2 Monabiphot (Nov 2018- Juillet 2019)

    • Izadora Mayumi Fujinami Tanimoto  Master 1 Monabiphot (Juillet-Octobre 2018)

    • Jean Roman PhD, ED SDSV, (2014-2018)

    Teaching

      • L1PC: Mechanics (TD15H)
      • L2PC: Optics (CM7,5H-TD9H-TP6H), PPP (9H), Electricity (24H TP)
      • L2PC: Solid Mechanics  (CM15H-TD13,5H-TP9H)
      • L2PC: Experimental Physics Projects (CM 6H-TP 28H)
      • M1 Functional Materials (Paris-Saclay): Polymers Phys. (CM9H-TD6H)
      • M2 innovative Mat.  (Paris-Saclay): Surface-interfaces (9H), confined environments (15H)
      • M1 Capes: Educational Sequences (9H)
      • M2 Int. Aggregation: Mechanics (CM3H-TP7H)

       

       

      Publication

        2023  
      • Greive, S.J., Bacri, L., Cressiot, B. and Pelta, J. 2023-12. Identification of Conformational Variants for Bradykinin Biomarker Peptides from a Biofluid Using a Nanopore and Machine Learning. ACS Nano 2023DOI: 10.1021/acsnano.3c08433
      • Stierlen, Aïcha ; Greive, Sandra J. ; Bacri, Laurent ; Manivet, Philippe ; Cressiot, Benjamin ; Pelta, Juan Nanopore Discrimination of Coagulation Biomarker Derivatives and Characterization of a Post-Translational Modification ACS Cent. Sci. 2023, Vol. 9, No. 2 p. 228-238 DOI: 10.1021/acscentsci.2c01256
        2022  
      • Fujinami Tanimoto, Izadora Mayumi ; Cressiot, Benjamin ; Greive, Sandra J. ; Le Pioufle, Bruno ; Bacri, Laurent ; Pelta, Juan  Focus on using nanopore technology for societal health, environmental and energy challenges  Nano Res2022, Vol. 15, No. 11 p. 9906-9920 DOI:10.1007/s12274-022-4379-2
      • Fujinami Tanimoto, Izadora Mayumi ; Zhang, Jiayi ; Cressiot, Benjamin ; Pioufle, Bruno Le ; Bacri, Laurent ; Pelta, Juan Dynamics of DNA Through Solid-state Nanopores Fabricated by Controlled Dielectric Breakdown Chemistry An Asian Journal 2022 , Vol. 17, No. 24 DOI: 10.1002/asia.202200888
        2021  

      Fujinami - Tanimoto, Izadora ; Cressiot, Benjamin : Jarroux, Nathalie ; Roman, Jean ; Patriarche, Gilles ; Le Pioufle, Bruno ; Pelta, Juan ; Bacri, Laurent}, Biosensors and Bioelectronics2021, 183 113195 DOI: 10.1016/j.bios.2021.113195

        2020  

      Cressiot, B.; Bacri, L. ; Pelta, J.The Promise of Nanopore Technology: Advances in the Discrimination of Protein Sequences and Chemical Modifications Small Methods, Wiley, 2020, 2000090

       

       

        2019  

      Cressiot, B.; Ouldali, H.; Pastoriza-Gallego, M.; Bacri, L.; van der Goot, F. ; Pelta, J. Aerolysin, a powerful protein sensor for fundamental studies and development of upcoming applications  ACS Sensors, 2019, 4, 530-548

        2018  
      1. Roman, J.; Francais, O.; Jarroux, N.; Patriarche, G.; Pelta, J.; Bacri, L. & Pioufle, B. L. Solid-state nanopore easy chip integration in a cheap and reusable microfluidic device for ion transport and polymer conformation sensing ACS Sensors,2018, 3, 2129-2137
      2. Fennouri, A.; Ramiandrisoa, J.; Bacri, L.; Mathé, J. & Daniel, R. Comparative biosensing of glycosaminoglycan hyaluronic acid oligo- and polysaccharides using aerolysin and alpha-hemolysin nanopores The European Physical Journal E, 2018, 41
      3. Roman, J.; Pioufle, B. L.; Auvray, L.; Pelta, J. & Bacri, L. From current trace to the understanding of confined media The European Physical Journal E, 2018, 41
      4. Mamad-Hemouch, H.; Bacri, L.; Huin, C.; Przybylski, C.; Thiebot, B.; Patriarche, G.; Jarroux, N. & Pelta, J. Versatile cyclodextrin nanotube synthesis with functional anchors for efficiency ion channel formation: design, characterization and ion conductance  Nanoscale, 2018, 10, 15303-15316
      5. Pastoriza-Gallego, M.; Thiébot, B.; Bacri, L.; Auvray, L. & Pelta, J. Dynamics of a polyelectrolyte through aerolysin channel as a function of applied voltage and concentrationstar The European Physical Journal E, Springer Nature, 2018, 41
      6. Bacri, L.; Mamad-Hemouch, H.; Przybylski, C.; Thiebot, B.; Patriarche, G.; Jarroux, N. & Pelta, J.
        Biomimetic ion channels formation by emulsion based on chemically modified cyclodextrin nanotubes Faraday Discuss , 2018, 210, 41-54
        2017  

      1.       Roman, J.; Jarroux, N.; Patriarche, G.; Français, O.; Pelta, J.*; Le Pioufle, B.*; Bacri, L.* Functionalized Solid-State Nanopore Integrated in a Reusable Microfluidic Device for a Better Stability and Nanoparticle Detection. ACS Appl Mater Interfaces2017, 9, 41634–41640DOI: 10.1021/acsami.7b14717

        2016  

      Roman, J.; Français, O.; Jarroux, N.; Patriarche, G.; Pelta, J.; Pioufle, B. L. ; Bacri, L. Nanoparticle Electrical Analysis and Detection with a Solid-state Nanopore in a Microfluidic Device Procedia Eng., 2016, 168, 1475 - 1478 DOI: 10.1016/j.proeng.2016.11.425

        2015  
      1. Mamad-Hemouch, H.; Ramoul, H.; Taha, M. A.; Bacri, L.; Huin, C.; Przybylski, C.; Oukhaled, A.; Thiebot, B.; Patriarche, G.; Jarroux, N.*; Pelta, J.* Biomimetic nanotubes based on cyclodextrins for ion-channel applications Nano Letters, 2015, 15, 7748–7754 DOI: 10.1021/acs.nanolett.5b03938
      2. Baaken, G.; Halimeh, I.; Bacri, L.; Pelta, J.; Oukhaled, A.; Behrends, J. C. High-Resolution Size-Discrimination of Single Nonionic Synthetic Polymers with a Highly Charged Biological Nanopore. ACS Nano, 2015, 9, 6443-6449 DOI: 10.1021/acsnano.5b02096
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